Sergel 20 is a drug that reduces the amount of acid produced in the stomach. Used to treat heartburn, heartburn, and esophageal problems. It is also used to prevent and treat stomach ulcers.
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A medication called Sergel 20 lowers the amount of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with them. As directed by your doctor, take Sergel 20.
Caution is advised when consuming alcohol with Sergel 20. Please consult your doctor.
Sergel 20 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Sergel 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
It is not known whether Sergel 20 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Sergel 20 is safe to use in patients with kidney disease. No dose adjustment of Sergel 20 is recommended. However, inform your doctor if you have any kidney disease.
Sergel 20 should be used with caution in patients with severe liver disease. Dose adjustment of Sergel 20 may be needed. Please consult your doctor.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sergel 20 is to be taken empty stomach.
Sergel 20 is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.
If you miss a dose of Sergel 20, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Esomeprazole is prescribed to treat chronic heartburn and other GERD symptoms.
Esomeprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase in the gastric parietal cell, suppressing gastric acid output. The first single optical isomer of a proton pump inhibitor, esomeprazole (S-isomer of omeprazole), provides superior acid control than racemic proton pump inhibitors.
Esomeprazole capsules contain an enteric-coated pellet version of esomeprazole magnesium for improved absorption. Peak plasma levels (Cmax) occur roughly 1.5 hours after oral dosing (Tmax). When the dose is increased, the Cmax increases correspondingly, and the area under the plasma concentration-time curve (AUC) increases thrice from 20 to 40 mg. The systemic bioavailability with repeated once-daily doses is around 90%, compared to 64% after a single dose. When compared to fasting conditions, the AUC following a single dosage of esomeprazole is reduced by 33-53 percent after food ingestion. At least one hour before meals, esomeprazole should be consumed.
Esomeprazole binds to plasma proteins 97 percent of the time. Over a concentration range of 2 20 mmol/L, plasma protein binding remains constant. In healthy volunteers, the apparent volume of distribution at a steady state is around 16 L.
Esomeprazole is extensively processed by the cytochrome P450 (CYP) enzyme system in the liver. Esomeprazole's metabolites have no anti-secretory properties. The CYP2C19 isoenzyme, which creates the hydroxy and desmethyl metabolites, is responsible for the majority of esomeprazole metabolism. The sulphone metabolite is formed by CYP3A4, which is responsible for the remaining proportion.
Healing of Erosive Esophagitis:
Acid-related Dyspepsia:
Esophagitis:
Symptomatic GERD:
Helicobacter Pylori eradication:
Zollinger-Ellison Syndrome:
Duodenal Ulcer:
CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole does not appear to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4 in vitro or in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.
Esomeprazole may be mixed with CYP2C19, the major metabolizing protein of esomeprazole. Co-administration of esomeprazole 30 mg and the CYP2C19 substrate diazepam reduced diazepam clearance by 45%. Elevated plasma levels of diazepam were observed 12 hours after his administration and thereafter. Esomeprazole inhibits corrosive gastric emptying. Esomeprazole may then interfere with the retention of drugs (ketoconazole, compressed salts, digoxin, etc.) for which gastric pH is an important determinant of bioavailability. Oral contraceptives, diazepam, phenytoin, or quinidine do not appear to affect the pharmacokinetic profile of esomeprazole.
Clarithromycin in combination therapy:
Concomitant use of esomeprazole, clarithromycin, and amoxicillin increases plasma levels of esomeprazole and 14-hydroxy clarithromycin.
In patients who have a history of hypersensitivity to any of the formulations, esomeprazole is not recommended.
In pregnant women, there are no sufficient and well-controlled trials. No teratogenic effects have been found in animal investigations. Esomeprazole excretion in milk has not been studied. If the use of esomeprazole is thought necessary, breastfeeding should be terminated.
Store in a dry area at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children's reach.
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